Histomorphology Evolution of Recurrent Atypical Teratoid/Rhabdoid Tumors
نویسندگان
چکیده
منابع مشابه
Alisertib is active as single agent in recurrent atypical teratoid rhabdoid tumors in 4 children.
BACKGROUND Aurora Kinase A (AURKA) encodes a protein that regulates the formation and stability of the mitotic spindle and is highly active in atypical teratoid rhabdoid tumors (ATRT) through loss of the INI1 tumor suppressor gene. Alisertib (MLN8237) inhibits AURKA in vitro and in vivo. Given the strong preclinical data supporting the use of alisertib for ATRT patients, we sought and obtained ...
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ژورنال
عنوان ژورنال: American Journal of Clinical Pathology
سال: 2015
ISSN: 0002-9173,1943-7722
DOI: 10.1093/ajcp/144.suppl2.023